VKORC1 and CYP2C9 polymorphisms related to adverse events in case-control cohort of anticoagulated patients
نویسندگان
چکیده
منابع مشابه
VKORC1 and CYP2C9 polymorphisms related to adverse events in case-control cohort of anticoagulated patients
Vitamin K antagonists (VKAs) are highly effective but have a narrow therapeutic index and require routine monitoring of the INR. The primary aim of pharmacogenetics (PGx) is to optimize patient care, achieving drug treatments that are personalized according to the genetic profile of each patient. The best-characterized genes involved in VKA PGx involve pharmacokinetics (VKORC1) and pharmacodyna...
متن کاملWarfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction
BACKGROUND Warfarin treatment has a narrow therapeutic range, requiring meticulous monitoring and dosage titration. Individual dosage requirement has recently partly been explained by genetic variation of the warfarin metabolizing enzyme CYP2C9 and the Vitamin K-activating enzyme VKORC1. In the WARIS-II study, comparing three different antithrombotic regimens after myocardial infarction, warfar...
متن کاملIdentification of CYP2C9 and VKORC1 polymorphisms in Iranian patients who are under warfarin therapy
BACKGROUND Although catalytic properties of different genetic polymorphisms of VKORC1 and CYP2C9 products have been identified, there is limited study available regarding warfarin dose requirement in Iranian patient population. This study investigates the impact of these polymorphisms on 115 patients, referred to Payvand Clinical and Specialty Laboratory for determining the appropriate dose of ...
متن کاملidentification of cyp2c9 and vkorc1 polymorphisms in iranian patients who are under warfarin therapy
background: although catalytic properties of different genetic polymorphisms of vkorc1 and cyp2c9 products have been identified, there is limited study available regarding warfarin dose requirement in iranian patient population. this study investigates the impact of these polymorphisms on 115 patients, referred to payvand clinical and specialty laboratory for determining the appropriate dose of...
متن کاملfrequency distribution of polymorphisms of cyp2c19, cyp2c9, vkorc1 and slco1b1 genes in the yakut population
allele frequencies of single nucleotide polymorphisms (snps) are variable among different populations; therefore the study of snps in ethnic groups is important for establishing the clinical significance of the screening of these polymorphisms. the main goal of the research is to study the polymorphisms of cyp2c9 , cyp2c19 , vkorc1 , and slco1b1 in yakuts. genomic dna from 229 yakut subjects we...
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ژورنال
عنوان ژورنال: Medicine
سال: 2016
ISSN: 0025-7974
DOI: 10.1097/md.0000000000005451